Core answer: Jesse Faden is missing after waking her brother. At the start of Resonant she drives the Aberrant into Dylan's chest to wake him from his coma, then disappears. The FBC is left directorless, Emily Pope becomes acting co-director, and Dylan's personal goal is finding her while Manhattan warps. She is not a playable character.

What Is Confirmed Going In

1How to Follow Her Story In-Game

Expectation Check

You Are WonderingReality
Is Jesse the lead again?No. The game is built on the role reversal: last time she searched for him, now he searches for her.
Did she die, turn, or join the new threat?That is the question the story is selling. The exact circumstances stay mysterious on purpose so you discover them through play.
What does "rogue / fishing" mean?The Board's line. Fans read it as her going off-book on her own mission, not a confirmed heel turn.

Common Mistakes to Avoid

Bottom line: the marketing itself is asking the same question - FBC Director Jesse Faden is missing, where is she, what is she up to. Dylan is the one who has to answer it, and the rest is what you play to find out.