Core answer: you are running three clocks at once - your own 66 HP (lowest in the roster), Osty's HP (the real tank), and Doom versus remaining enemy HP (the team execution line). Players wipe when they treat Osty as optional, split the deck half-Osty half-Doom, or let teammates overkill past a Doom threshold.

How Osty and Doom Actually Work

1How to Play the Fight

Key Decisions

SituationBuild line
Early Act 1 / hallway multi-hitsOsty tank. Grab Summons, Grave Warden, Negative Pulse, Unleash.
Already have 40-80 Osty HP plus Reanimate/Unleash/SacrificeSpend it - Osty bomb line.
Partner is high damage-per-turnLean Doom. Your job is the number on the enemy, not racing their DPS.
Best reported duosIronclad (you control, they hit) or Regent (Osty covers their setup, then Doom + Stars delete)
Praised trioIronclad + Silent + Necrobinder - Poison walks enemies into Doom
Two or four NecrobindersStacked Doom plus shared Souls; meme-strong and chaotic. Note: Necro Mastery only reflects damage to your own Osty.
Do not half-commit. Messy hybrid lists are what make Necrobinder feel weak.
When Osty is dead, revive next turn via Summon or relic. Do not play Osty-attacks (Unleash, Flatten, Poke) into a corpse - they do nothing.

Common Mistakes to Avoid

Reference Images

Osty as a giant hand next to Necrobinder
Osty as a giant hand next to Necrobinder - the visual players keep posting
Self-Doom plus big Osty screenshot
Self-Doom plus big Osty - the screenshot players used when the engine clicked